Compartmentalized Microfluidic Platforms: The Unrivaled Breakthrough of In Vitro Tools for Neurobiological Research

• Tipo: Artigo em Revista Científica Internacional
• Data: 2016

Autores

Neto, E (Autor) Outra; Leitao, L (Autor) Outra; Sousa, DM (Autor) Outra; Alves, CJ (Autor) Outra; Alencastre, IS (Autor) Outra; Paulo Aguiar (Autor) FMUP; Lamghari, M (Autor) Outra

Revista

Título: Journal of Neuroscience

Vol. 36

ISSN: 0270-6474

Editora: Society for Neuroscience

Indexação

ISI Web of Knowledge - 66 Citações

Scopus - 63 Citações

Outras Informações

ID Authenticus: P-00M-84Y

DOI: 10.1523/jneurosci.1748-16.2016

Abstract (EN): Microfluidic technology has become a valuable tool to the scientific community, allowing researchers to study fine cellular mechanisms with higher variable control compared with conventional systems. It has evolved tremendously, and its applicability and flexibility made its usage grow exponentially and transversely to several research fields. This has been particularly noticeable in neuroscience research, where microfluidic platforms made it possible to address specific questions extending from axonal guidance, synapse formation, or axonal transport to the development of 3D models of the CNS to allow pharmacological testing and drug screening. Furthermore, the continuous upgrade of microfluidic platforms has allowed a deeper study of the communication occurring between different neuronal and glial cells or between neurons and other peripheral tissues, both in physiological and pathological conditions. Importantly, the evolution of microfluidic technology has always been accompanied by the development of new computational tools addressing data acquisition, analysis, and modeling.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 12