The Prenatal Origin of Hemispheric Asymmetry: An In Utero Neuroimaging Study

• Tipo: Artigo em Revista Científica Internacional
• Data: 2011

Autores

Kasprian, G (Autor) Outra; Langs, G (Autor) Outra; Brugger, PC (Autor) Outra; Bittner, M (Autor) Outra; Weber, M (Autor) Outra; Arantes, M (Autor) Outra; Prayer, D (Autor) Outra

Revista

Título: Cerebral Cortex

Vol. 21

Páginas: 1076-1083

ISSN: 1047-3211

Editora: Oxford University Press

Indexação

ISI Web of Knowledge - 83 Citações

Scopus - 105 Citações

Outras Informações

ID Authenticus: P-002-S2Q

DOI: 10.1093/cercor/bhq179

Abstract (EN): Anatomical and functional hemispheric lateralization originates from differential gene expression and leads to asymmetric structural brain development, which initially appears in the perisylvian regions by 26 gestational weeks (GWs). In this in vivo neuroimaging study, we demonstrated a predominant pattern of temporal lobe (TL) asymmetry in a large cohort of human fetuses between 18 and 37 GWs. Over two-thirds of fetuses showed a larger, left-sided TL, combined with the earlier appearance of the right superior temporal sulcus by 23 GWs (vs. 25 GWs on the left side), which was also deeper than its left counterpart in the majority of cases (94.2%). Shape analysis detected highly significant differences in the contour of the right and left TLs by 20 GWs. Thus, fetal hemispheric asymmetry can be detected in utero, opening new diagnostic possibilities for the assessment of diseases that are believed to be linked to atypical hemispheric lateralization.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8