Factors associated with the development of cirrhosis in patients with HCV chronic infection

• Tipo: Artigo em Revista Científica Internacional
• Data: 2005

Autores

Mario Dinis Ribeiro (Autor) Outra; Ramalho, F (Autor) Outra; Gloria, H (Autor) Outra; Marinho, R (Autor) Outra; Raimundo, M (Autor) Outra; Serejo, F (Autor) Outra; Velosa, J (Autor) Outra; Carneiro de Moura, M (Autor) Outra

Revista

Título: Hepato-Gastroenterology

Vol. 52

Páginas: 176-179

ISSN: 0172-6390

Editora: Thieme

Indexação

ISI Web of Knowledge - 6 Citações

Scopus - 5 Citações

Outras Informações

ID Authenticus: P-000-5TP

Abstract (EN): Background/Aims: The natural history of chronic hepatitis C virus (HCV) infection still has some details to be established, namely in what concerns progression to hepatic cirrhosis (HQ. The study aims to define predictive factors for progression to HC in patients with HCV chronic infection. Methodology: A cross-sectional study was performed on 129 patients consecutively submitted to liver biopsy. Thirty-six percent (n=46) had HC at histological evaluation. Results: Patients with HC did not show statistically significant differences on gender, viruses genotypes, alcohol consumption or proportion of positivity to markers of previous hepatitis B virus (HBV) infection -anti-HBc/anti-HBs+. Patients with HC seem to have had their infection sporadically (50%) or post-transfusion (35%) -p=0.052, and iv drugs addiction was related to non-HC patients (39%) -p=0.006. Age at infection, time of infection and positivity for anti-HBc/anti-HBs were factors independently related to HC (multivariate analysis). Patients older than 40 years by the time of infection [OR=4.5 (95% CI = 1.9-10.81, those with less than 5 years of time of infection [OR= 4.2 (95% CI = 1.6-10.8)], and patients with previous HBV infection [OR=2.51 (1.00-6.69)] are at higher risk for HC. Conclusions: We argue that older patients, with a shorter time interval between HCV infection and diagnosis, and namely those with markers for previous HBV infection represent patients with higher risk for progression to hepatic cirrhosis.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4