Vascular biomarkers and correlation with peripheral vasculopathy in systemic sclerosis

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2015

Autores

Chora, I (Autor) FMUP; Guiducci, S (Autor) Outra; Manetti, M (Autor) Outra; Romano, E (Autor) Outra; Mazzotta, C (Autor) Outra; Bellando Randone, S (Autor) Outra; Ibba Manneschi, L (Autor) Outra; Matucci Cerinic, M (Autor) Outra; soares, r (Autor) FMUP

Revista

Título: Autoimmunity Reviews

Vol. 14

Páginas: 314-322

ISSN: 1568-9972

Editora: Elsevier

Indexação

ISI Web of Knowledge - 48 Citações

Scopus - 48 Citações

Outras Informações

ID Authenticus: P-00A-6GZ

DOI: 10.1016/j.autrev.2014.12.001

Abstract (EN): Vascular disease is a hallmark of systemic sclerosis (SSc). It is present in every patient, being responsible both for the earliest clinical manifestations and the major life-threatening complications of the disease, and thus determining important morbidity and mortality. In SSc, progressive vascular injury leads to vascular tone dysfunction and reduced capillary blood flow, with consequent tissue ischemia and chronic hypoxia. These phenomena are often accompanied by abnormal levels of vascular factors. Microangiopathy in SSc may be easily assessed by nailfold videocapillaroscopy. The variety of derangements detected in the nailfold capillaries is accompanied by abnormal levels of different vascular mediators and appears to be the best evaluable predictor of the development of peripheral vascular complications, such as digital ulcers. The purpose of this review is to summarize in SSc the most relevant vascular biomarkers and the main associations between vascular biomarkers and capillaroscopic parameters and/or the presence of digital ulcers. Vascular biomarkers could become useful predictive factors of vascular damage in SSc, allowing an earlier management of vascular complications.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9