P-cadherin is up-regulated by the antiestrogen ICI 182,780 and promotes invasion of human breast cancer cells

• Tipo: Artigo em Revista Científica Internacional
• Data: 2004

Autores

Joana Paredes (Autor) Outra; Stove, C (Autor) Outra; Stove, V (Autor) Outra; Milanezi, F (Autor) Outra; Van Marck, V (Autor) Outra; Derycke, L (Autor) Outra; Mareel, M (Autor) Outra; Bracke, M (Autor) Outra; Fernando Schmitt (Autor) FMUP

Revista

A Revista está pendente de validação pelos Serviços Administrativos.

Título: CANCER RESEARCH

Vol. 64

Páginas: 8309-8317

ISSN: 0008-5472

Indexação

ISI Web of Knowledge - 60 Citações

Scopus - 62 Citações

Outras Informações

ID Authenticus: P-000-7QJ

DOI: 10.1158/0008-5472.can-04-0795

Abstract (EN): P-cadherin expression in breast carcinomas has been associated with tumors of high histologic grade and lacking estrogen receptor-alpha, suggesting a link between these proteins. In the MCF-7/AZ breast cancer cell line, blocking estrogen receptor-alpha signaling with the antiestrogen ICI 182,780 induced an increase of P-cadherin, which coincided with induction of in vitro invasion. Retroviral transduction of MCF-7/AZ cells, as well as HEK 293T cells, showed the proinvasive activity of P-cadherin, which requires the juxtamembrane domain of its cytoplasmic tail. This study establishes a direct link between P-cadherin expression and the lack of estrogen receptor-alpha signaling in breast cancer cells and suggests a role for P-cadherin in invasion, through its interaction with proteins bound to the juxtamembrane domain.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9