3-Substituted coumarins as dual inhibitors of AChE and MAO for the treatment of Alzheimer's disease

• Tipo: Artigo em Revista Científica Internacional
• Data: 2012

Autores

Viña, D (Autor) Outra; Matos, MJ (Autor) Outra; Yáñez, M (Autor) Outra; Santana, L (Autor) Outra; Uriarte, E (Autor) Outra

Revista

Título: MedChemComm

Vol. 3

Páginas: 213-218

ISSN: 2040-2503

Editora: Royal Society of Chemistry

Indexação

Scopus - 75 Citações

Outras Informações

ID Authenticus: P-00R-0MP

DOI: 10.1039/c1md00221j

Abstract (EN): The complex etiology of Alzheimer's disease (AD) has encouraged active research in the development of multi-target drugs with two or more complementary biological activities, since they may represent an important advance in the treatment of this disease. A series of 3-substituted coumarins were synthesized and evaluated as monoamino oxidases (MAO) and acetylcholinesterase (AChE) inhibitors. Most of the 3-benzamide coumarin derivatives inhibited both MAO-B and AChE with values in the micromolar range. It might be a promising direction for developing novel drugs as potential agents for the treatment of AD patients. © 2012 The Royal Society of Chemistry.

Idioma: Inglês

Tipo (Avaliação Docente): Científica