Neutrophil Elastase Inhibitors and Chronic Kidney Disease

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2018

Autores

Bronze da Rocha, E (Autor) FFUP; Alice Santos Silva (Autor) FFUP

Revista

Título: International Journal of Biological Sciences

Vol. 14

Páginas: 1343-1360

ISSN: 1449-2288

Editora: Ivyspring International Publisher

Indexação

ISI Web of Knowledge - 35 Citações

Scopus - 35 Citações

Outras Informações

ID Authenticus: P-00P-JXX

DOI: 10.7150/ijbs.26111

Abstract (EN): End-stage renal disease (ESRD), the last stage of chronic kidney disease (CKD), is characterized by chronic inflammation and oxidative stress. Neutrophils are the front line cells that mediate an inflammatory response against microorganisms as they can migrate, produce reactive oxygen species (ROS), secrete neutrophil serine proteases (NSPs), and release neutrophil extracellular traps (NETs). Serine proteases inhibitors regulate the activity of serine proteases and reduce neutrophil accumulation at inflammatory sites. This review intends to relate the role of neutrophil elastase in CKD and the effects of neutrophil elastase inhibitors in predicting or preventing inflammation.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 18