Singlet oxygen generation using a porous monolithic polymer supported photosensitizer: potential application to the photodynamic destruction of melanoma cells

• Tipo: Artigo em Revista Científica Internacional
• Data: 2009

Autores

Isabel Burguete, MI (Autor) Outra; Galindo Rosales, FJ (Autor) Outra; Gavara, R (Autor) Outra; Luis, SV (Autor) Outra; Moreno, M (Autor) Outra; Thomas, P (Autor) Outra; Russell, DA (Autor) Outra

Revista

Título: Photochemical & Photobiological Sciences

Vol. 8

Páginas: 37-44

ISSN: 1474-905X

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 20 Citações

Scopus - 29 Citações

Outras Informações

ID Authenticus: P-005-5X7

DOI: 10.1039/b810921d

Abstract (EN): Photogeneration of singlet oxygen ((1)O(2)) by rose bengal is improved through the use of a porous monolithic polymer (PMP) as a support, as compared to a classic gel-type resin matrix. This type of monolithic polymeric matrix can be made at a multigram scale in quantitative yields enabling the preparation of large amounts of supported photosensitizer at low cost. The singlet oxygen induced oxidation of 9,10-diphenylanthracene has been used as a benchmark reaction, and a comparative study using rose bengal in solution, entrapped within gel-type derived polymer and entrapped within a porous monolithic polymer (PMP) has been performed. The enhanced photoreactivity of the PMP-rose bengal conjugates has been utilised for the successful photodynamic therapy (PDT) of melanoma cells.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8