IFN-gamma-Dependent Reduction of Erythrocyte Life Span Leads to Anemia during Mycobacterial Infection

• Tipo: Artigo em Revista Científica Internacional
• Data: 2019

Autores

Gomes, AC (Autor) Outra; Moreira, AC (Autor) Outra; Silva, T (Autor) Outra; Neves, JV (Autor) Outra; Mesquita, G (Autor) Outra; Agostinho Almeida (Autor) FFUP; Barreira Silva, P (Autor) Outra; Fernandes, R (Autor) Outra; Resende, M (Autor) Outra; Appelberg, R (Autor) ICBAS; Rodrigues, P (Autor) ICBAS; Gomes, MS (Autor) ICBAS

Revista

Título: Journal of Immunology

Vol. 203

Páginas: 2485-2496

ISSN: 0022-1767

Editora: American Association of Immunologists

Indexação

ISI Web of Knowledge - 22 Citações

Scopus - 22 Citações

Outras Informações

ID Authenticus: P-00R-3EQ

DOI: 10.4049/jimmunol.1900382

Abstract (EN): Anemia is a frequent and challenging complication of mycobacterial infections. We used a model of disseminated Mycobacterium avium infection in mice to investigate the mechanisms of mycobacteria-induced anemia. We found increased formation of RBC in the bone marrow and spleen of infected mice. Infection induced reticulocytosis and the premature egress of immature progenitors to the systemic circulation in an IFN-gamma (IFNG)-dependent way. The newly formed RBC had reduced CD47 surface expression and a reduced life span and were phagocytosed in the liver of infected mice, increasing iron recycling in this organ. The increased engulfment and degradation of RBC was independent of IFNG sensing by macrophages. Together, our findings demonstrate that mycobacterial infection alters the formation of erythrocytes, leading to their accelerated removal from circulation and hemolytic anemia. This comprehensive elucidation of the mechanisms underlying mycobacteria-induced anemia has important implications for its efficient clinical management.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 12