Delphinidin-3-O-glucoside inhibits angiogenesis via VEGFR2 downregulation and migration through actin disruption

• Tipo: Artigo em Revista Científica Internacional
• Data: 2019

Autores

Viegas, Olga (Autor) FCNAUP; Faria, MA (Autor) Outra; Sousa, JB (Autor) Outra; Vojtek, M (Autor) Outra; Goncalves Monteiro, S (Autor) Outra; Suliburska, J (Autor) Outra; Diniz, C (Autor) FFUP; Ferreira, Isabel (Autor) FFUP

Revista

Título: Journal of Functional Foods

Vol. 54

Páginas: 393-402

ISSN: 1756-4646

Editora: Elsevier

Indexação

ISI Web of Knowledge - 8 Citações

Scopus - 11 Citações

Classificação Científica

CORDIS: Ciências da Saúde

FOS: Ciências médicas e da saúde

Outras Informações

ID Authenticus: P-00Q-DJW

DOI: 10.1016/j.jff.2019.01.039

Abstract (EN): Excessive angiogenesis favours cancer development, allowing cancer invasion. Polyphenols are promising chemopreventive agents, although data gather so far in respect of anthocyanins, namely cyanidin-3-O-glucoside and delphinidin-3-O-glucoside (DG) and respective aglycones are scarce. The capability of these compounds to prevent tumour progression by inhibiting angiogenesis/cell migration/proliferation was studied in: (i) chicken embryo chorioallantoic membrane assay; (ii) MDA-MB-231/MCF-12A cells to study proliferation and vascular endothelial growth factor receptor-2 (VEGFR-2) expression and cytoskeleton dynamics; (iii) in vitro assay to evaluate gastrointestinal digestion. The studied compounds promoted alterations on actin re/disassembly to form protrusions/stress fibres, evidencing capability to disrupt actin cytoskeleton dynamics and inhibiting angiogenesis, at least in part, by VEGFR-2 downregulation, with DG presenting the higher effect. Anthocyanin evidenced selectivity towards cancer cells by eliciting cytotoxicity on MDA-MB-231 cells and having a slight effect on healthy cells. Thus, DG evidenced the most promising profile as dietary supplement to achieve the biological desired effects.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10