The Evolutionary Dynamics of the Lion Panthera leo Revealed by Host and Viral Population Genomics

• Tipo: Artigo em Revista Científica Internacional
• Data: 2008

Autores

Agostinho Antunes (Autor) Outra; Troyer, JL (Autor) Outra; Roelke, ME (Autor) Outra; Pecon Slattery, J (Autor) Outra; Packer, C (Autor) Outra; Winterbach, C (Autor) Outra; Winterbach, H (Autor) Outra; Hemson, G (Autor) Outra; Frank, L (Autor) Outra; Stander, P (Autor) Outra; Siefert, L (Autor) Outra; Driciru, M (Autor) Outra; Funston, PJ (Autor) Outra; Alexander, KA (Autor) Outra; Prager, KC (Autor) Outra; Mills, G (Autor) Outra; Wildt, D (Autor) Outra; Bush, M (Autor) Outra; O'Brien, SJ (Autor) Outra; Johnson, WE (Autor) Outra

Revista

Título: Plos Genetics

Vol. 4

ISSN: 1553-7390

Editora: Public Library of Science

Indexação

ISI Web of Knowledge - 80 Citações

Scopus - 89 Citações

Outras Informações

ID Authenticus: P-003-VB9

DOI: 10.1371/journal.pgen.1000251

Abstract (EN): The lion Panthera leo is one of the world's most charismatic carnivores and is one of Africa's key predators. Here, we used a large dataset from 357 lions comprehending 1.13 megabases of sequence data and genotypes from 22 microsatellite loci to characterize its recent evolutionary history. Patterns of molecular genetic variation in multiple maternal (mtDNA), paternal (Y-chromosome), and biparental nuclear (nDNA) genetic markers were compared with patterns of sequence and subtype variation of the lion feline immunodeficiency virus (FIV(Ple)), a lentivirus analogous to human immunodeficiency virus (HIV). In spite of the ability of lions to disperse long distances, patterns of lion genetic diversity suggest substantial population subdivision (mtDNA Phi(ST) = 0.92; nDNA F(ST) = 0.18), and reduced gene flow, which, along with large differences in seroprevalence of six distinct FIV(Ple) subtypes among lion populations, refute the hypothesis that African lions consist of a single panmictic population. Our results suggest that extant lion populations derive from several Pleistocene refugia in East and Southern Africa (similar to 324,000-169,000 years ago), which expanded during the Late Pleistocene (similar to 100,000 years ago) into Central and North Africa and into Asia. During the Pleistocene/Holocene transition (similar to 14,000-7,000 years), another expansion occurred from southern refugia northwards towards East Africa, causing population interbreeding. In particular, lion and FIV(Ple) variation affirms that the large, well-studied lion population occupying the greater Serengeti Ecosystem is derived from three distinct populations that admixed recently.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 11