Time-varying pharmacodynamics in a simple non-integer HIV infection model

• Tipo: Artigo em Revista Científica Internacional
• Data: 2019-01-01

Autores

João Tavares (Autor) FCUP; Carla Pinto (Autor) Outra

Revista

Título: Mathematical Biosciences

Vol. 307

Páginas: 1-12

ISSN: 0025-5564

Editora: Elsevier

Indexação

ISI Web of Knowledge - 1 Citação

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-00P-W52

DOI: 10.1016/j.mbs.2018.11.001

Abstract (EN): In this paper we study the effect of time-varying drug exposure in the dynamics of a fractional order model for the human immunodeficiency virus infection. We compute the reproduction number of the model and verify the stability of the disease-free equilibrium. The model is simulated for parameters directly modelling the pharmacodynamics of HIV, namely the slope of the dose-response curve, the drug's half-life, and the dosing interval. The later affect in a significant way the infection patterns. The order of the fractional derivative is also a key player of the model, adding more information, which could be useful for a deeper understanding of the pharmacodynamics of HIV, necessary for more accurate therapeutic regimens.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 12