SAM-Based Immunosensor for the Analysis of Thyroxine (T4)

• Tipo: Artigo em Revista Científica Internacional
• Data: 2017

Autores

Couto, RAS (Autor) Outra; Goncalves, LM (Autor) Outra; Goes, MS (Autor) Outra; Rodrigues, CMP (Autor) Outra; M. Beatriz Q. Garcia (Autor) FFUP; Rodrigues, JA (Autor) FCUP

Revista

Título: Journal of the Electrochemical Society

Vol. 164 Nº 2

Páginas: B103-B106

ISSN: 0013-4651

Editora: Electrochemical Society, Inc.

Indexação

ISI Web of Knowledge - 13 Citações

Scopus - 14 Citações

Outras Informações

ID Authenticus: P-00N-NH0

DOI: 10.1149/2.0561704jes

Abstract (EN): In this work T4, also known as thyroxine, a thyroid hormone with many relevant roles in human metabolism, was determined with an antibody-based biosensor, consisting on a multi thiol self-assembled monolayer (SAM) whereas a selective antibody was attached. Electroanalytical measurements were performed by impedance on a ferricyanide redox probe. A limit of detection of 1.5 ng mL(-1) and limit of quantification (LOQ) of 4.0 ngmL(-1) were obtained. This biosensor is a proof-of-concept for the creation of point-of-care electrochemical approach for the quantification of T4.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4