Sensibility of the quorum growth thresholds controlling local immune responses

• Tipo: Artigo em Revista Científica Internacional
• Data: 2008

Autores

Burroughs, NJ (Autor) Outra; Bruno M P M Oliveira (Autor) FCNAUP; Alberto A. Pinto (Autor) Outra; Sequeira, HJT (Autor) Outra

Revista

Título: Mathematical and Computer Modelling

Vol. 47 Nº 7

Páginas: 714-725

ISSN: 0895-7177

Editora: Pergamon Press - Elsevier

Indexação

ISI Web of Knowledge - 14 Citações

Scopus - 14 Citações

Outras Informações

ID Authenticus: P-004-0N3

DOI: 10.1016/j.mcm.2007.06.007

Abstract (EN): The consequences of regulatory T cell (Treg) inhibition of interleukine 2 secretion are examined by mathematical modelling. We demonstrate that cytokine dependent growth exhibits quorum T cell population thresholds that determine whether immune responses develop on activation and whether the immune system returns to a control state. We study the effects in the quorum T cell population thresholds, by the T cell maximum growth rate, by the growth rate ratio between Tregs and T cells, by the value of the secretion rate of cytokines, and by the effectiveness of T cell secretion inhibition by Tregs.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 12