UNUSUAL GROWTH-CHARACTERISTICS OF HUMAN-MELANOMA XENOGRAFTS IN THE NUDE-MOUSE - A MODEL FOR DESMOPLASIA, DORMANCY AND PROGRESSION

• Tipo: Artigo em Revista Científica Internacional
• Data: 1992

Autores

Fátima Gärtner (Autor) Outra; FEARNS, C (Autor) Outra; WILSON, EL (Autor) Outra; CAMPBELL, JAH (Autor) Outra; DOWDLE, EB (Autor) Outra

Revista

Título: British Journal of Cancer

Vol. 65

Páginas: 487-490

ISSN: 0007-0920

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 27 Citações

Scopus - 26 Citações

Outras Informações

ID Authenticus: P-008-P5S

DOI: 10.1038/bjc.1992.101

Abstract (EN): When human melanoma cells are injected into nude mice they usually give rise to tumours that grow progressively and do not elicit a prominent host response. We have recently developed a melanoma cell line, UCT-Mel 7, that did not show these characteristics. In the first place UCT-Mel 7 showed a consistently unusual, phasic growth pattern. After a short initial period of limited growth (phase 1), the tumour ceased growing and remained static for 2-3 months (phase 2). The tumour then regressed (phase 3) to enter a second period of quiescence (phase 4) which was eventually broken by the emergence of a rapidly growing lethal tumour (phase 5). Of particular interest was the fact that the rate at which the tumours grew correlated closely with their collagen content. During the prolonged, phase 2 plateau, the tumours were intensely desmoplastic; rapidly growing phase 5 tumours, that had escaped from dormancy, contained very little collagen and virtually no reticulin. This cell line helps to fill an important need for an experimental system for the study of desmoplasia, dormancy and progression.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4