Overexpressing leptin genetic polymorphism (-2548 G/A) is associated with susceptibility to prostate cancer and risk of advanced disease

• Tipo: Artigo em Revista Científica Internacional
• Data: 2004

Autores

Ribeiro, R (Autor) Outra; Vasconcelos, A (Autor) Outra; Costa, S (Autor) Outra; Pinto, D (Autor) Outra; Morais, A (Autor) Outra; Oliveira, J (Autor) Outra; Lobo, F (Autor) Outra; Lopes, C (Autor) ICBAS; Medeiros, R (Autor) ICBAS

Revista

Título: Prostate

Vol. 59

Páginas: 268-274

ISSN: 0270-4137

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 82 Citações

Scopus - 89 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

Outras Informações

ID Authenticus: P-000-ACT

DOI: 10.1002/pros.20004

Abstract (EN): BACKGROUND. Leptin has been consistently associated with angiogenesis and tumoral growth. A G/A single nucleotide polymorphism (SNP) at the -2548 site in leptin gene (LEP) is associated with overexpression of leptin (A-allele). METHODS. We evaluated DNA samples from 268 (536 alleles) unrelated individuals, 118 healthy controls (HCs) and 150 prostate cancer (PC) patients, for leptin gene (LEP) locus -2548 genotypes. RESULTS. We found an overrepresentation of the A-allele in PC patients and that there is a significantly higher risk for PC among A carriers (OR = 1.60; confidence interval (CI), 1.13-2.28, P = 0.008). Linear trend analysis showed that quantitative increase of A-allele presence was associated with significantly higher risk for PC (P = 0.003) in heterozygous (OR = 2.11; CI, 1.20-3.71) and homozygous (OR = 2.93; Cl, 1.27-6.75) genotypes. Furthermore, the AA and AG genotypes represent significantly higher risk (OR = 4.67; CI, 1.69-12.88 and OR = 2.58; CI, 1.19-5.58, respectively) for advanced disease. CONCLUSIONS. According to our results we hypothesize that the polymorphism in LEP gene may be relevant to PC risk and progression, supporting the hypothesis for leptin involvement in cancer ethiopathogenesis. (C) 2003 Wiley-Liss, Inc.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7