Do microglia arise from pericytes? An ultrastructural and distribution study in the rat cerebellar cortex

• Tipo: Artigo em Revista Científica Internacional
• Data: 1996

Autores

monteiro, raf (Autor) Outra; rocha, e (Autor) ICBAS; mariniabreu, mm (Autor) Outra

Revista

Título: Journal of Submicroscopic Cytology and Pathology

Vol. 28

Páginas: 457-469

ISSN: 1122-9497

Editora: N I E Nuova Immagine Editrice

Indexação

ISI Web of Knowledge - 7 Citações

Scopus - 8 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Ciências biológicas

Outras Informações

ID Authenticus: P-001-DM2

Abstract (EN): Both pericytes and microglia are dark cells that may present similar ultrastructure as well as organization of the rough endoplasmic reticulum cisternae; in addition, images that suggest pericytes being released from the basal lamina compartment, some of them looking like forms of perivascular microglia, may be found. Anatomical articulations between pericytes and microglia are observed. A distribution analysis reveals that, in the considered five neocerebellar cortical strata, the percentage of pericytes preponderates over the percentage of microglia; furthermore, there is a highly statistically significant linear trend between the percentages of pericytes and of microglia in connection with their distribution along the cortical strata. This study suggests that, in rat cerebellar cortex, microglia may arise from pericytes. It is also hypothesized that astroglia have an active role in releasing pericytes from the vascular wall.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 13