Delayed recruitment of lymphocytes into the lungs of CD30-deficient mice during aerogenic Mycobacterium avium infections

• Tipo: Artigo em Revista Científica Internacional
• Data: 2009

Autores

Manuela Florido (Autor) Outra; Shaun R McColl (Autor) Outra; Rui Appelberg (Autor) ICBAS

Revista

Título: Immunobiology

Vol. 214

Páginas: 643-652

ISSN: 0171-2985

Editora: Elsevier

Indexação

ISI Web of Knowledge - 1 Citação

Scopus - 1 Citação

Pubmed / Medline

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

CORDIS: Ciências da Saúde > Ciências Médicas > Medicina > Infecções

Outras Informações

ID Authenticus: P-00H-APD

DOI: 10.1016/j.imbio.2008.12.002

Abstract (EN): CD30 is a member of the tumor necrosis factor-receptor superfamily, a group of receptors known to act as accessory molecules in the development of the immune response. Control and CD30-deficient mice were aerogenically infected with Mycobacterium avium. Although the mycobacterial loads in the lungs were similar in both strains of mice, CD30-deficient animals exhibited delayed structuring of pulmonary granulomas and reduced recruitment of lymphocytes throughout a 240 days period of infection. Discrete alterations in the chemokine network were detected in the CD30-deficient animals although they showed no clear relation to the deficient inflammatory response. Thus CD30/CD 153 interactions are involved in lung immune-mediated inflammation.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10