Targeting Glycosylation: A New Road for Cancer Drug Discovery

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2020

Autores

Costa, AF (Autor) Outra; Campos, D (Autor) Outra; Celso Reis (Autor) ICBAS; Gomes, C (Autor) Outra

Revista

A Revista está pendente de validação pelos Serviços Administrativos.

Título: TRENDS IN CANCER

Vol. 6

Páginas: 757-766

ISSN: 2405-8033

Editora: CELL PRESS

Indexação

ISI Web of Knowledge - 60 Citações

Scopus - 65 Citações

Outras Informações

ID Authenticus: P-00S-1X3

DOI: 10.1016/j.trecan.2020.04.002

Abstract (EN): Cancer is a deadly disease that encompasses numerous cellular modifications. Among them, alterations in glycosylation are a proven reliable hallmark of cancer, with most biomarkers used in the clinic detecting cancer-associated glycans. Despite their clear potential as therapy targets, glycans have been overlooked in drug discovery strategies. The complexity associated with the glycosylation process, and lack of specific methodologies to study it, have long hampered progress. However, recent advances in new methodologies, such as glycoengineering of cells and high-throughput screening (HTS), have opened new avenues of discovery. We envision that glycan-based targeting has the potential to start a new era of cancer therapy. In this article, we discuss the promise of cancer-associated glycosylation for the discovery of effective cancer drugs.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10