TERTp mutations and p53 expression in head and neck cutaneous basal cell carcinomas with different aggressive features

• Tipo: Artigo em Revista Científica Internacional
• Data: 2021

Autores

Castanheira, A (Autor) Outra; Vieira, MJ (Autor) Outra; Pinto, M (Autor) Outra; Dias, C (Autor) Outra; Prada, L (Autor) Outra; Macedo, S (Autor) Outra; Fernandes, MS (Autor) Outra; Vieira, F (Autor) Outra; Soares, P (Autor) FMUP; Alberto Mota (Autor) FMUP; Lopes, JM (Autor) FMUP; Boaventura, P (Autor) Outra

Revista

Título: Scientific Reports

Vol. 11

ISSN: 2045-2322

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 3 Citações

Scopus - 2 Citações

Outras Informações

ID Authenticus: P-00T-WWF

DOI: 10.1038/s41598-021-89906-w

Abstract (EN): Cutaneous basal cell carcinoma (cBCC) is an economic burden to health services, due to its great morbidity and increasing incidence in old people. Infiltrative cBCCs and cBCCs with micronodular pattern are considered as more aggressive. The role of p53 expression and TERTp mutation on cBCC behavior remains to be clarified. We aimed to assess TERTp mutations and p53 expression in relation to the cBCC histological subtype in a cohort of patients referred to an ENT Department of a tertiary Hospital of Northern Portugal. We performed a retrospective clinicopathological and histological review of the head and neck cBCCs followed-up at the otorhinolaryngology department of Tras-os-Montes e Alto Douro hospital (January 2007-June 2018). We assessed TERTp mutations in 142 cBCCs and p53 protein expression, through immunohistochemistry, in 157 cBCCs. We detected TERTp mutations in 43.7% of cBCCs and p53 overexpression in 60.5% of cBCCs. We spotted association of p53 overexpression and TERTp mutation with necrosis. In the infitrative-growth pattern cBCCs, there was no significant association with the clinical and histological features evaluated, except for necrosis. In the indolent-growth cBCCs, we identified a significant association of TERTp mutation status with female sex, necrosis, multiple cBCCs, and p53 positive expression. Our results suggest that TERTp mutation may be useful to identify more aggressive features in the indolent-growth pattern cBCCs (nodular and superficial subtypes). Further studies with larger cohorts are warranted to clarify the relevance of TERTp mutation in cBCCs.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10