ENDOTHELIUM-DERIVED OXIDATIVE STRESS MAY CONTRIBUTE TO EXERCISE-INDUCED MUSCLE DAMAGE

• Tipo: Artigo em Revista Científica Internacional
• Data: 1993

Autores

DUARTE, JAR (Autor) FADEUP; APPELL, HJ (Autor) Outra; CARVALHO, F (Autor) FFUP; BASTOS, ML (Autor) FFUP; SOARES, JMC (Autor) Outra

Revista

Título: International Journal of Sports Medicine

Vol. 14

Páginas: 440-443

ISSN: 0172-4622

Editora: Thieme

Indexação

ISI Web of Knowledge - 61 Citações

Scopus - 92 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Ciências da saúde

Outras Informações

ID Authenticus: P-001-MGK

DOI: 10.1055/s-2007-1021207

Abstract (EN): In exercise-induced muscle damage, oxidative stress derived from the liberation of reactive oxygen species (ROS) is assumed to be of etiological importance. Xanthine oxidase (XO) located in capillary endothelium is one of the possible sources for ROS, mainly investigated so far under conditions of ischemia/reperfusion. XO can be inhibited by allopurinol. To investigate the contribution of XO for the oxidative stress-induced development of muscle damage, mice were subjected to a single bout of exhaustive running exercise. Another exercised group received allopurinol. The reduced form of glutathione (GSH) was measured to estimate the amount of oxidative stress in soleus muscle, and the same muscle was examined in the light and electron microscope at different periods of time (0, 48, 96 h) after exercise. While exercise alone resulted in a marked reduction of GSH indicative for oxidative stress, which only recovered at 96 h, the administration of allopurinal to exercised animals induced a complete recovery already at 48 h after exercise. Muscle damage was more pronounced in the exercised animals which had not been treated with allopurinol. It is concluded that endothelium-derived ROS contribute reasonably to oxidative stress to exercised muscle and to fiber and capillary damage.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4