The association between 25(OH)D levels, frailty status and adiposity indices in older adults

• Tipo: Artigo em Revista Científica Internacional
• Data: 2018

Autores

Santos, A.R.S. (Autor) FCNAUP; Afonso, Cláudia (Autor) FCNAUP; Santos, Alejandro (Autor) FCNAUP; Borges, Nuno (Autor) FCNAUP; Moreira, Pedro (Autor) FCNAUP; Padrão, Patrícia (Autor) FCNAUP; Fonseca, I (Autor) Outra; Amaral, Teresa (Autor) FCNAUP

Classificação Científica

CORDIS: Ciências da Saúde

FOS: Ciências médicas e da saúde

Outras Informações

ID Authenticus: P-00P-TYG

DOI: 10.1101/330340

Abstract (EN): <jats:p>Background: Vitamin D deficiency is common in older adults and has been linked with frailty and obesity, but it remains to be studied whether frail obese older adults are at higher risk of vitamin D deficiency. Therefore, the aim of this study is to explore the association between frailty, adiposity indices and serum 25(OH)D concentrations. Methods: 1447 individuals with 65 years or older, participating in a cross-sectional study (Nutrition UP 65). Frailty, according to Fried et al., body mass index (BMI), waist circumference (WC), body roundness index (BRI) and body shape index (ABSI) were evaluated. A stepwise multinomial logistic regression was carried out to quantify the association between 25(OH)D quartiles and independent variables. Results: Median 25(OH)D levels were lower in individuals presenting both frailty and obesity (p<0.001). In the multivariate analysis, pre-frailty (OR 2.65; 95% CI 1.63-4.32) and frailty (OR 3.76; 95% CI 2.08-6.81) were associated with increased odds of lower 25(OH)D serum levels (first quartile). Regarding adiposity indices, obesity (OR 1.75; 95% CI 1.07-2.87) and the highest categories of WC (OR 3.46; 95% CI 1.95-6.15), BRI (OR 4.35; 95% CI 2.60-7.29) and ABSI (OR 3.17 95% CI 1.86-5.38) were directly associated with lower 25(OH)D serum levels (first quartile). Conclusions: A positive association between frailty or obesity and lower levels of vitamin D was found. Moreover, besides BMI and WC, other indicators of body adiposity, such as BRI and ABSI, were associated with lower 25(OH)D serum concentrations.</jats:p>

Idioma: Inglês

Tipo (Avaliação Docente): Científica