Assessing the potential application of X-chromosomal haploblocks in population genetics and forensic studies

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Pereira, V (Author) Other; Tomas, C (Author) Other; Pietroni, C (Author) Other; Andersen, JD (Author) Other; Fordyce, SL (Author) Other; Pinto, N (Author) Other; Mikkelsen, M (Author) Other; Borsting, C (Author) Other; Amorim, A (Author) FCUP; Gusmao, L (Author) Other; Prata, MJ (Author) FCUP; Morling, N (Author) Other

Journal

Title: Forensic Science International: Genetics Supplement Series

Vol. 4

Pages: e9-e10

ISSN: 1875-1768

Publisher: Elsevier

Indexing

ISI Web of Knowledge

Scopus - 1 Citation

Other information

Authenticus ID: P-008-JD6

DOI: 10.1016/j.fsigss.2013.10.004

Abstract (EN): Haploblocks are segments of the genome with little recombination that may be of interest in forensic and population genetics. Criteria to select autosomal haploblocks have been previously described, leading to the identification of candidate regions that, a priori, met the conditions to be used as forensic genetic markers. Still, the potential of X-chromosomal haploblocks remains unexplored. The present work aimed to provide basis for designing strategies for selection of X-haploblocks defined by single nucleotide polymorphisms (SNPs) using next generation sequencing approach. The potential application in population genetics and forensic studies was addressed. One of the conditions considered in the haploblock selection was the simultaneous inclusion of short tandem repeats (STRs) currently used in forensic casework to allow the distinction between SNP-defined haplotypes and increase the resolution for fine-scale studies. Given the size of the X chromosome (~150. Mbps), only four haploblocks could be selected in order to guarantee their independence. © 2013 Elsevier Ireland Ltd.

Language: English

Type (Professor's evaluation): Scientific