Classification of Fibroepithelial Lesions of the Breast in Core Needle Biopsy With Implications for Further Management

• Type: Another Publication in an International Scientific Journal
• Date: 2025

Authors

Rakha, EA (Author) Other; Quinn, C (Author) Other; Raymond, W (Author) Other; Allison, KH (Author) Other; Badve, SS (Author) Other; Brogi, E (Author) Other; Callagy, G (Author) Other; Charafe Jauffret, E (Author) Other; Chen, CJ (Author) Other; Chen, YY (Author) Other; Collins, LC (Author) Other; Cserni, G (Author) Other; Djerroudi, L (Author) Other; Jaffer, S (Author) Other; Foschini, MP (Author) Other; Gobbi, H (Author) Other; Gudi, M (Author) Other; Harada, O (Author) Other; Kulka, J (Author) Other; Kuroda, H (Author) Other; Lakhani, SR (Author) Other; Li, XX (Author) Other; Moriya, T (Author) Other; O'Toole, SA (Author) Other; Pinder, SE (Author) Other; Provenzano, E (Author) Other; Sahin, AA (Author) Other; Fernando Schmitt (Author) FMUP; Shaaban, AM (Author) Other; Siziopikou, KP (Author) Other; Tang, P (Author) Other; Tse, GM (Author) Other; Varga, Z (Author) Other; Vincent Salomon, A (Author) Other; Wen, HN (Author) Other; Yamaguchi, R (Author) Other; Yang, WT (Author) Other; Fox, SB (Author) Other; Schnitt, SJ (Author) Other; Ellis, IO (Author) Other; Tan, PH (Author) Other

Journal

Title: Modern Pathology

Vol. 38

ISSN: 0893-3952

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 1 Citation

Other information

Authenticus ID: P-018-B1N

DOI: 10.1016/j.modpat.2025.100734

Abstract (EN): Fibroepithelial lesions (FELs) of the breast represent a diverse group of biphasic tumors with varying morphologies and clinical behavior. The classification of FELs is mainly based on a constellation of diagnostic criteria, and intralesional heterogeneity is not uncommon. Therefore, reporting FELs in a core needle biopsy (CNB) with limited tissue material can be challenging as not all the features may be represented for assessment. Differentiating a classic fibroadenoma from a well-sampled phyllodes tumor (PT) is generally straightforward. However, cellular fibroadenoma, morphologically heterogeneous benign PT, and myoid hamartoma can overlap histologically. Accurate grading of PT is also challenging on CNB and carries significant management implications. In this article, we provide an overview and propose a pragmatic approach to reporting FELs on CNB, particularly for lesions with overlapping features. Guidance using the UK/European B classification of FELs alongside descriptive reporting of the various lesions, is also presented to aid in management decisions. (c) 2025 THE AUTHORS. Published by Elsevier Inc. on behalf of the United States & Canadian Academy of Pathology. This is an open access article under the CC BY license (http://creativecommons.org/ licenses/by/4.0/).

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 21