Neoplastic Multifocal Skin Lesions: Biology, Etiology, and Targeted Therapies for Nonmelanoma Skin Cancers

• Type: Another Publication in an International Scientific Journal
• Date: 2018

Authors

Fernandes, AR (Author) Other; Santos, AC (Author) Other; Sanchez Lopez, E (Author) Other; Kovacevic, AB (Author) Other; Espina, M (Author) Other; Calpena, AC (Author) Other; Veiga, FJ (Author) Other; Garcia, ML (Author) Other; Souto, EB (Author) Other

Journal

The Journal is awaiting validation by the Administrative Services.

Title: SKIN PHARMACOLOGY AND PHYSIOLOGY

Vol. 31

Pages: 59-73

ISSN: 1660-5527

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 11 Citations

Other information

Authenticus ID: P-00N-RGS

DOI: 10.1159/000479529

Abstract (EN): Neoplastic skin lesions are multifocal, diffuse skin infiltrations of particular relevance in the differential diagnosis of ulcerative, nodular, or crusting skin lesions. Nonmelanoma skin cancers (NMSCs), namely, basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and also actinic keratosis (AK), are the most common malignant tumors in humans. BCCs do not proliferate rapidly and most of the times do not metastasize, while SCCs are more infiltrative, metastatic, and destructive. AKs are precursor lesions of cutaneous SCCs. The classical therapy of NMSCs makes use of photodynamic therapy associated with chemotherapeutics. With improved understanding of the pathological mechanisms of tumor initiation, progression, and differentiation, a case is made towards the use of targeted chemotherapy with the intent to reduce the cytotoxicity of classical treatments. The present review aims to describe the current state of the art on the knowledge of NMSC, including its risks factors, oncogenes, and skin carcinogenesis, discussing the classical therapy against new therapeutic options. (C) 2017 S. Karger AG, Basel

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 15