In vitro effect of fibrinogen on Candida albicans germ tube formation

• Type: Article in International Scientific Journal
• Date: 1999

Authors

rodrigues, ag (Author) FMUP; pina-vaz, c (Author) FMUP; Mardh, PA (Author) Other; Da Fonseca, AF (Author) Other; De Oliveira, JM (Author) Other

Journal

Title: APMIS: acta pathologica, microbiologica, et immunologica Scandinavica

Vol. 107

Pages: 1020-1022

ISSN: 0903-4641

Publisher: John Wiley & Sons

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 6 Citations

Other information

Authenticus ID: P-001-2WF

DOI: 10.1155/s1064744994000074

Abstract (EN): Pseudohyphae formation by Candida albicans blastoconidia, as seen in vaginal smears, is a phenotypical change commonly assumed to mean fungal invasiveness, i.e. not mere colonization. C. albicans forms germ tubes in vitro in the presence of serum. In our search for inhibitory components of germ tube formation, we decided to study fibrinogen, The inhibition of germ tube formation by clinical isolates of C. albicans was evaluated iu the presence of serial concentrations of fraction I, type TV and fraction I, type Is of fibrinogen from bovine plasma. Fibrinogen showed a dose-dependent, pH-independent inhibitory effect on the germ tube formation by C. albicans.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 3