Assessment of the potential of Bonelike (R) graft for bone regeneration by using an animal model

• Type: Another Publication in an International Scientific Journal
• Date: 2005

Authors

Lobato, JV (Author) Other; Hussain, NS (Author) Other; Botelho, CM (Author) Other; Rodrigues, JM (Author) FMUP; Luis, AL (Author) Other; Mauricio, AC (Author) ICBAS; Lopes, MA (Author) FEUP; Santos, JD (Author) FEUP

Indexing

ISI Web of Knowledge - 9 Citations

Scopus - 11 Citations

Scientific classification

FOS: Engineering and technology > Materials engineering

Other information

Authenticus ID: P-000-58P

Abstract (EN): Bonelike((R)) graft that mimics the inorganic composition of bone tissue has been developed and characterized over the last decade. To evaluate the osteoconductivity of Bonelike((R)) two granule size ranges, one ranging from 150-250 mu m and the other from 250-500 mu m were implanted in the femurs of New Zealand White rabbits, aiming at being clinically used in different medical applications, such as dentistry and orthopaedics. In order to facilitate the medical application of the Bonelike((R)) graft the use of a commercially available polymeric vehicle was also analyzed. Radiological examination, histological studies and scanning electron microscopy (SEM) analyses revealed that the surface of Bonelike((R)) granules was almost completely surrounded by new bone formation after 12 weeks of implantation, which proves its highly osteoconductive behaviour.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4