The development and validation of the Portuguese risk score for detecting type 2 diabetes and impaired fasting glucose

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Gray, LJ (Author) Other; Barros H (Author) FMUP; Raposo, L (Author) Other; Khunti, K (Author) Other; Davies, MJ (Author) Other; Santos AC (Author) FMUP

Journal

Title: Primary Care Diabetes

Vol. 7

Pages: 11-18

ISSN: 1751-9918

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 10 Citations

Scopus - 11 Citations

Other information

Authenticus ID: P-005-29Z

DOI: 10.1016/j.pcd.2013.01.003

Abstract (EN): Aims: To develop and validate a non-invasive score for detecting undiagnosed impaired fasting glucose (IFG) and type 2 diabetes (T2DM) in a Portuguese population. Methods: We used data from 3,374 individuals aged 18-94 years from a Portuguese cross-sectional study. We developed a logistic regression model for predicting IFG/T2DM (diagnosed using fasting glucose). We externally validated the score using data from two cohorts of the EPI-Porto study, cross-sectional (n = 2,131) and data from the 5 year follow-up (n =1,304). Results: The final model included age, sex, BMI and hypertension with an area under the ROC curve of 70.1 (95%CI 68.4, 71.7). Using a cut-point which classifies 50% of the EPI-Porto cross-sectional data as high-risk gave sensitivity 73.2% (95%CI 68.5%, 77.6%), specificity 55.5% (53.1%, 57.8%), positive predictive value (PPV) 27.0% (24.3%, 29.8%) and negative predictive value (NPV) 90.2% (88.3%, 92.0%) for IFG/T2DM. Using the same cut-point on the prospective data classified 45% as high-risk; sensitivity 69.1% (63.4%, 74.4%), specificity 63.3% (60.0%, 66.5%), PPV 38.0% (33.9%, 42.4%), and NPV 86.2% (83.3%, 88.8%). Conclusion: The Portuguese risk score can be used to identify those at high risk of both prevalent undiagnosed and incident IFG/T2DM.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8