| Summary: |
This project aims the development of novel vaginal meshes, less strong and stiff, that match the physiologic biomechanics of vaginal support. The technology of melt electrospinning equipment, with additive manufacturing capability, to produce complex 3D structures from micron scale fibers, in direct 3D printing mode will be developed and tested. New concepts bioabsorbable/biodegradable meshes/scaffolds with new geometries, for pelvic floor prolapse repair will be developed. A 3D model of the vagina, capable of simulating the effect of alternative mesh reinforcement and suspension /fixation techniques of pelvic cavity muscles and organs will also be studied. The validation of the novel meshes and optimization of its design will be done by means of in vitro mesh cell ingrowth studies.
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