Is selection at mtDNA really a major concern?

• Tipo: Artigo em Livro de Atas de Conferência Internacional
• Data: 2004

Autores

Pereira, L (Autor) Outra; Amorim, A (Autor) FCUP

Ata de Conferência Internacional

Título: PROGRESS IN FORENSIC GENETICS 10

Páginas: 109-111

20th International Congress of the International-Society-for-Forensic-Genetics

Arcachon, FRANCE, SEP 09-13, 2003

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Outras ciências médicas

Outras Informações

ID Authenticus: P-000-DHZ

DOI: 10.1016/s0531-5131(03)01838-7

Abstract (EN): Evidence for selection on human mtDNA has been obtained from the results of some widely used tests: (a) higher replacement (R) to synonymous (S) substitution ratios in human genes ND2, CO1, ATP6, CO3 and CytB (and overall) than expected by human/chimpanzee comparisons; (b) distributions of absolute (K/(K+S)) and corrected (for coding degeneracy; Ka/(Ka+Ks)) frequencies for R are heterogeneous for human mtDNA genes (higher for ATP6, ATP8 and CytB); and (c) no correlation between gene length-R (in opposition to gene length-S). However, a mere 8.3% of sequences show R/(R + S) greater than or equal to 0.5 and, furthermore, R/S ratio is strongly correlated with haplogroup classification based on HVR variability. Demographic history seems therefore enough to explain the observed diversity in human mtDNA coding region, with older haplogroups showing lower R/S ratios than younger ones.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 3