Redox Metabolism in Mitochondria of Trypanosomatids

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2013

Autores

tomas, am (Autor) FCUP; castro, h (Autor) Outra

Revista

Título: ANTIOXIDANTS & REDOX SIGNALING

Vol. 19

Páginas: 696-707

ISSN: 1523-0864

Editora: Mary Ann Liebert

Indexação

ISI Web of Knowledge - 1 Citação

Scopus - 4 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Ciências biológicas

Outras Informações

ID Authenticus: P-006-7XA

DOI: 10.1089/ars.2012.4948

Abstract (EN): Significance: In the single mitochondrion of protozoan trypanosomatid parasites there are several sites for the generation and elimination of reactive oxygen species (ROS), a class of molecules that exhibit a dual role in cells, either as regulatory mediators or as cytotoxic effectors. Recent Advances: Formation of ROS in trypanosomatid mitochondria can be induced by various drug compounds. Importantly, it can also be triggered by specific physiologic stimuli, indicating that this phenomenon may occur in living parasites as well. Elimination of ROS in these organelles is attributed to the activity of two iron-dependent superoxide dismutases (FeSODs) and up to three different peroxidases (a cytochrome c peroxidase and two thiol peroxidases). Critical Issues: Data regarding the formation of ROS in trypanosomatid mitochondria are limited and nonsystematic. Another critical issue refers to the exact contribution of mitochondrial FeSODs and peroxidases for ROS removal, given that their antioxidant activity is not essential when abrogated individually. This suggests some level of functional overlapping or that ROS produced in mitochondria under normal conditions can be removed noncatalytically. Also still unsolved is the mechanism by which mitochondrial thiol peroxidases are regenerated to their reduced (active) form. Future Directions: The production of intramitochondrial ROS under physiologic conditions and their implication in parasite biology should be further clarified. The relative importance of enzymatic versus nonenzymatic mechanisms for ROS elimination in trypanosomatid mitochondria also requires investigation. Simultaneous depletion of several redundant antioxidant enzymes and determination of noncatalytic antioxidants are possible ways to achieve this.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 12