Failure to induce enhanced protection against tuberculosis by increasing T-cell-dependent interferon-gamma generation

• Tipo: Artigo em Revista Científica Internacional
• Data: 2001

Autores

Leal, IS (Autor) Outra; Smedegard, B (Autor) Outra; Andersen, P (Autor) Outra; Appelberg, R (Autor) ICBAS

Revista

Título: Immunology

Vol. 104

Páginas: 157-161

ISSN: 0019-2805

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 45 Citações

Scopus - 46 Citações

Pubmed / Medline

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

CORDIS: Ciências da Saúde > Ciências Médicas > Medicina > Infecções

Outras Informações

ID Authenticus: P-000-T4S

DOI: 10.1046/j.1365-2567.2001.01305.x

Abstract (EN): We evaluated the use of recombinant human interleukin-6 (rhIL-6) and a monoclonal antibody specific for interferon-gamma (IFN-gamma) as co-adjuvants in a subunit vaccine against tuberculosis consisting of the culture filtrate proteins of Mycobacterium tuberculosis (ST-CF) emulsified in the adjuvant dimethyl-dioctadecylammonium bromide (DDA). Both the addition of rhIL-6 and the neutralization of IFN-gamma resulted in an increased T helper type 1 (Th1) response characterized by enhanced IFN-gamma production and cell proliferation. Nevertheless, this did not result in the enhancement of protection against either an intravenous or an aerosol M. tuberculosis challenge. Our data stress the need to identify further correlates of protection in addition to IFN-gamma production to screen vaccines against tuberculosis infection.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5