Compressed matrix core tablet as a quick/slow dual-component delivery system containing ibuprofen

• Tipo: Artigo em Revista Científica Internacional
• Data: 2007

Autores

lopes, cm (Autor) Outra; lobo, jms (Autor) Outra; pinto, jf (Autor) Outra; costa, pc (Autor) FFUP

Revista

Título: AAPS PharmSciTech

Vol. 8 Nº 3

Páginas: E1-E8

ISSN: 1530-9932

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 43 Citações

Scopus - 48 Citações

Outras Informações

ID Authenticus: P-004-C9M

DOI: 10.1208/pt0803051

Abstract (EN): The purpose of the present research was to produce a quick/slow biphasic delivery system for ibuprofen. A dual-component tablet made of a sustained release tableted core and an immediate release tableted coat was prepared by direct compression. Both the core and the coat contained a model drug ( ibuprofen). The sustained release effect was achieved with a polymer ( hydroxypropyl methylcellulose [ HPMC] or ethylcellulose) to modulate the release of the drug. The in vitro drug release profile from these tablets showed the desired biphasic release behavior: the ibuprofen contained in the fast releasing component was dissolved within 2 minutes, whereas the drug in the core tablet was released at different times (approximate to 16 or > 24 hours), depending on the composition of the matrix tablet. Based on the release kinetic parameters calculated, it can be concluded that the HPMC core was suitable for providing a constant and controlled release ( zero order) for a long period of time.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8