The role of ayahuasca in cell viability and oxidative stress in gastric adenocarcinoma cell line

• Tipo: Artigo em Revista Científica Internacional
• Data: 2024

Autores

Gonçalves, J (Autor) Outra; Cascalheira, JF (Autor) Outra; Patricia Valentao (Autor) FFUP; Luís, A (Autor) Outra; Gallardo, E (Autor) Outra; Duarte, AP (Autor) Outra

Revista

Título: Natural Product Research

Páginas: 1-5

ISSN: 1478-6419

Editora: Taylor & Francis

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-010-ZMG

DOI: 10.1080/14786419.2024.2375315

Abstract (EN): Ayahuasca, a psychoactive beverage native to the Amazon, originally derived from Banisteriopsis caapi stem scrapings and Psychotria viridis leaves, exhibits hallucinogenic properties due to N,N-dimethyltryptamine. When combined with beta-carbolines, it enters the bloodstream and central nervous system, inhibiting monoamine oxidase-A. Over time, therapeutic effects have been associated to ayahuasca consumption. This study assessed the impact of extracts from three plant decoctions used in ayahuasca preparation on the gastric adenocarcinoma cell line (AGS). MTT reduction assays selected B. caapi, Mimosa hostilis, and Peganum harmala samples as most effective. Lactate dehydrogenase activity evaluated membrane integrity loss, while oxidative stress induction was measured using dihydroethidium and 2 ',7 '-dichlorodihydrofluorescein diacetate probes. Results revealed apoptosis induction in AGS cells, with all three samples significantly reducing oxidative stress. [GRAPHICS] .

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5