Computational modeling of cellular effects post-irradiation with low-and high-LET particles and different absorbed doses

• Tipo: Artigo em Revista Científica Internacional
• Data: 2013

Autores

Adriana Alexandre S. Tavares (Autor) FEUP; João Manuel R. S. Tavares (Autor) FEUP

Revista

Título: Dose-Response

Vol. 11 Nº 2

Páginas: 191-206

ISSN: 1559-3258

Editora: International Dose-Response Society

Indexação

ISI Web of Knowledge - 2 Citações

ISI Web of Science

Scopus - 4 Citações

Classificação Científica

FOS: Ciências médicas e da saúde

CORDIS: Ciências da Saúde

Outras Informações

ID Authenticus: P-005-387

DOI: 10.2203/dose-response.11-049.tavares

Abstract (EN): The use of computational methods to improve the understanding of biological responses to various types of radiation is an approach where multiple parameters can be modelled and a variety of data is generated. This study compares cellular effects modelled for low absorbed doses against high absorbed doses. The authors hypothesized that low and high absorbed doses would contribute to cell killing via different mechanisms, potentially impacting on targeted tumour radiotherapy outcomes. Cellular kinetics following irradiation with selective low- and high-linear energy transfer (LET) particles were investigated using the Virtual Cell (VC) radiobiology algorithm. Two different cell types were assessed using the VC radiobiology algorithm: human fibroblasts and human crypt cells. The results showed that at lower doses (0.01 to 0.2 Gy), all radiation sources used were equally able to induce cell death (p>0.05, ANOVA). On the other hand, at higher doses (1.0 to 8.0 Gy), the radiation response was LET and dose dependent (p<0.05, ANOVA). The data obtained suggests that the computational methods used might provide some insight into the cellular effects following irradiation. The results also suggest that it may be necessary to re-evaluate cellular radiation-induced effects, particularly at low doses that could affect therapeutic effectiveness.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 16