pH and male fertility: making sense on pH homeodynamics throughout the male reproductive tract

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2019

Autores

Bernardino, RL (Autor) ICBAS; Carrageta, DF (Autor) Outra; Sousa, M (Autor) Outra; Alves, MG (Autor) Outra; Oliveira, PF (Autor) FMUP

Revista

Título: Cellular and Molecular Life Sciences

Vol. 76

Páginas: 3783-3800

ISSN: 1420-682X

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 21 Citações

Scopus - 23 Citações

Outras Informações

ID Authenticus: P-00Q-HRQ

DOI: 10.1007/s00018-019-03170-w

Abstract (EN): In the male reproductive tract, ionic equilibrium is essential to maintain normal spermatozoa production and, hence, the reproductive potential. Among the several ions, HCO3- and H+ have a central role, mainly due to their role on pH homeostasis. In the male reproductive tract, the major players in pH regulation and homeodynamics are carbonic anhydrases (CAs), HCO3- membrane transporters (solute carrier 4-SLC4 and solute carrier 26-SLC26 family transporters), Na+-H+ exchangers (NHEs), monocarboxylate transporters (MCTs) and voltage-gated proton channels (Hv1). CAs and these membrane transporters are widely distributed throughout the male reproductive tract, where they play essential roles in the ionic balance of tubular fluids. CAs are the enzymes responsible for the production of HCO3- which is then transported by membrane transporters to ensure the maturation, storage, and capacitation of the spermatozoa. The transport of H+ is carried out by NHEs, Hv1, and MCTs and is essential for the electrochemical balance and for the maintenance of the pH within the physiological limits along the male reproductive tract. Alterations in HCO3- production and transport of ions have been associated with some male reproductive dysfunctions. Herein, we present an up-to-date review on the distribution and role of the main intervenient on pH homeodynamics in the fluids throughout the male reproductive tract. In addition, we discuss their relevance for the establishment of the male reproductive potential.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 18