Solid dispersion of praziquantel enhanced solubility and improve the efficacy of the schistosomiasis treatment

• Tipo: Artigo em Revista Científica Internacional
• Data: 2018

Autores

Marques, CSF (Autor) Outra; Rezende, P (Autor) Outra; Andrade, LN (Autor) Outra; Mendes, TMF (Autor) Outra; Allegretti, SM (Autor) Outra; Bani, C (Autor) Outra; Chaud, MV (Autor) Outra; de Almeida, MB (Autor) Outra; Souto, EB (Autor) Outra; da Costa, LP (Autor) Outra; Severino, P (Autor) Outra

Revista

Título: Journal of Drug Delivery Science and Technology

Vol. 45

Páginas: 124-134

ISSN: 1773-2247

Editora: Editions de Sante

Indexação

ISI Web of Knowledge - 11 Citações

Scopus - 15 Citações

Outras Informações

ID Authenticus: P-00N-XEF

DOI: 10.1016/j.jddst.2018.03.009

Abstract (EN): Praziquantel (PZQ) is an anthelmintic of choice in the treatment of schistosomiasis. Solvent evaporation technique produced three different Solid Dispersions (SD) (drug: polymer, w/w) with sodium alginate (ALG) or carboxymethylcellulose (CMC). Characterization was done by X-Ray Diffraction (XRD), Fourier Transformed Infrared spectroscopy (FTIR) and Scanning Electron Microscopy (SEM), thermal analysis (DSC/TG), cell viability and in vitro assay against S. mansoni. The results of SD with different ratios revealed that the 1:0.25 ratio of PZQ with ALG showed higher solubility. The morphological structure change to the lamellar structure that it was confirmed with XRD. Then, thermal analyses and FTIR indicating a significant interaction between PZQ and polymer in SD indicate a change in the molecular mobility of the drug. In a culture of S. mansoni, we observed that SD is leading the death of the parasites. Regarding cytotoxicity, SD does not show toxicity in fibroblasts cells.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 11