A novel approach based on lipid nanoparticles (SLN (R)) for topical delivery of alpha-lipoic acid

• Tipo: Artigo em Revista Científica Internacional
• Data: 2005

Autores

Souto, EB (Autor) Outra; Muller, RH (Autor) Outra; Gohla, S (Autor) Outra

Revista

Título: Journal of Microencapsulation

Vol. 22

Páginas: 581-592

ISSN: 0265-2048

Editora: Taylor & Francis

Indexação

ISI Web of Knowledge - 44 Citações

Scopus - 60 Citações

Outras Informações

ID Authenticus: P-00F-RVN

DOI: 10.1080/02652040500162378

Abstract (EN): This study describes the development, preparation and characterization of solid lipid nanoparticles (SLN(R)) containing the novel anti-ageing substance alpha-lipoic acid. Lipoic acid is chemically labile, i.e. the degradation products possess an unpleasant odour. Therefore, the active was encapsulated in SLN. A lipid with low melting point ( Softisan (R)601) was selected for preparation of active-loaded SLN after screening the solubility of alpha-lipoic acid in physicochemically different lipids. An entrapment efficiency of 90% (UV analysis) was obtained for all developed formulations using Miranol (R)Ultra C32 as emulsifying agent. Particle size stability was monitored during 3 months storing the samples at 20 degrees C and at 4 degrees C. Results of DSC analysis confirm that these systems are characterized by a solid-like behaviour, although with a very low crystallinity index.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 12