SOLID LIPID NANOPARTICLE FORMULATIONS: PHARMACOKINETIC AND BIOPHARMACEUTICAL ASPECTS IN DRUG DELIVERY

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2009

Autores

Souto, EB (Autor) Outra; Doktorovova, S (Autor) Outra

Revista

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Título: METHODS IN ENZYMOLOGY, VOL 497: SYNTHETIC BIOLOGY, METHODS FOR PART/DEVICE CHARACTERIZATION AND CHASSIS ENGINEERING, PT A

Vol. 33

Páginas: 105-129

ISSN: 0076-6879

Editora: ELSEVIER ACADEMIC PRESS INC

Indexação

ISI Web of Knowledge - 44 Citações

Scopus - 62 Citações

Outras Informações

ID Authenticus: P-003-RAV

DOI: 10.1016/s0076-6879(09)64006-4

Abstract (EN): Solid lipid nanoparticles (SLNs) have emerged as important tools to modify the release profile for a large number of drugs including protein and peptide molecules. SLNs are produced from biocompatible and biodegradable lipid materials, making them a promising therapeutic strategy for drug targeting and delivery, and surmounting the inherent limitations of regulation acceptance. Due to their versatility in loading both lipophilic and hydrophilic molecules in the solid lipid matrix, SLNs depict the ability to prolong, extend or sustain the release profile of the loaded molecules, therefore reducing the repeated administration, and increasing the therapeutic value of a certain treatment. Additional advantages include reduction of drug toxicity and increase of drug bioavailability. To develop SLN formulations for drug targeting and delivery, a basic pharmacokinetic understanding of drug distribution is of major relevance, as well as the biopharmaceutical aspects of the administration route. This chapter provides a fundamental understanding of the pharmacokinetic properties of SLNs, which influence both biopharmaceutical and clinical profiles of the loaded molecules.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 25