Quality of evidence of anti-obesity pharmacotherapy: An overview of systematic reviews [Qualidade de evidência de farmacoterapia anti-obesidade: Uma overview de revisões sistemáticas]

• Tipo: Artigo em Revista Científica Internacional
• Data: 2018

Autores

Lucchetta, RC (Autor) Outra; Riveros, BS (Autor) Outra; Pontarolo, R (Autor) Outra; Radominski, RB (Autor) Outra; Fernandez Llimos, F (Autor) Outra; Correr, CJ (Autor) Outra

Revista

Título: Revista de Ciencias Farmaceuticas Basica e Aplicada

Vol. 39 Nº 1

Páginas: 1-11

ISSN: 1808-4532

Editora: Universidade Estadual Paulista - UNESP

Indexação

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-00T-J5J

Abstract (EN): The safety and effectiveness of main anti-obesity drugs are controversial, and there is no consensus among regulatory agencies regarding anti-obesity drugs. We undertook an overview of systematic reviews (SR) of randomized controlled trials (RCT) to summarize the quality of evidence related to anti-obesity drugs. Data sources included Medline, Scopus, The Cochrane Library and PROSPERO. Twenty-one SR (564 RCT; average of 2,356 participants per review) satisfied the inclusion criteria. Ten SR presented a high level of heterogeneity, and only five SR included sensitivity analyses. The most important limitations reported by the SR were a high level of attrition, a small sample size, and a short follow-up. Eight different outcomes for efficacy were used, 15 different outcomes for biomarkers were used, and nine different outcomes for safety were used. Conclusions: In conclusion, the quality of SR pertaining to anti-obesity drugs is low, and these reviews have a high level of heterogeneity. Future SR should present more detailed population inclusion criteria, larger sample sizes, and focus variables reported in a predefined anti-obesity core outcome set.

Idioma: Inglês

Tipo (Avaliação Docente): Científica