The Pebble/Rho1/Anillin pathway controls polyploidization and axonal wrapping activity in the glial cells of the Drosophila eye

• Tipo: Artigo em Revista Científica Internacional
• Data: 2021

Autores

Tavares, L (Autor) Outra; Gracio, P (Autor) Outra; Ramos, R (Autor) Outra; Traquete, R (Autor) Outra; Relvas, JB (Autor) FMUP; Pereira, PS (Autor) Outra

Revista

Título: Developmental Biology

Vol. 473

Páginas: 90-96

ISSN: 0012-1606

Editora: Elsevier

Indexação

ISI Web of Knowledge - 0 Citações

Outras Informações

ID Authenticus: P-00T-R09

DOI: 10.1016/j.ydbio.2021.02.002

Abstract (EN): During development glial cell are crucially important for the establishment of neuronal networks. Proliferation and migration of glial cells can be modulated by neurons, and in turn glial cells can differentiate to assume key roles such as axonal wrapping and targeting. To explore the roles of actin cytoskeletal rearrangements in glial cells, we studied the function of Rho1 in Drosophila developing visual system. We show that the Pebble (RhoGEF)/ Rho1/Anillin pathway is required for glia proliferation and to prevent the formation of large polyploid perineurial glial cells, which can still migrate into the eye disc if generated. Surprisingly, this Rho1 pathway is not necessary to establish the total glial membrane area or for the differentiation of the polyploid perineurial cells. The resulting polyploid wrapping glial cells are able to initiate wrapping of axons in the basal eye disc, however the arrangement and density of glia nuclei and membrane processes in the optic stalk are altered and the ensheathing of the photoreceptor axonal fascicles is reduced.

Idioma: Inglês

Tipo (Avaliação Docente): Divulgação

Nº de páginas: 7