Platinum(II) Ring-Fused Chlorins as Near-Infrared Emitting Oxygen Sensors and Photodynamic Agents

• Tipo: Artigo em Revista Científica Internacional
• Data: 2017

Autores

Pereira, NAM (Autor) Outra; Laranjo, M (Autor) Outra; Casalta Lopes, J (Autor) Outra; Serra, AC (Autor) Outra; Pineiro, M (Autor) Outra; Pina, J (Autor) Outra; Sergio Seixas de Melo, JSS (Autor) Outra; Senge, MO (Autor) Outra; Filomena Botelho, MF (Autor) Outra; Martelo, L (Autor) Outra; Burrows, HD (Autor) Outra; Pinho e Melo, TMVDE (Autor) Outra

Revista

Título: Acs Medicinal Chemistry Letters

Vol. 8

Páginas: 310-315

ISSN: 1948-5875

Editora: American Chemical Society

Indexação

ISI Web of Knowledge - 43 Citações

Scopus - 44 Citações

Outras Informações

ID Authenticus: P-00M-HQC

DOI: 10.1021/acsmedchemlett.6b00476

Abstract (EN): Novel near-infrared luminescent compounds based on platinum(II) 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-fused chlorins are described. These compounds have high photostability and display light emission, in particular simultaneous fluorescence and phosphorescence emission in solution at room temperature, in the biologically relevant 700-850 nm red and near -infrared (NIR) spectral region, making them excellent materials for biological imaging. The simultaneous presence of fluorescence and phosphorescence emission at room temperature, with the phosphorescence strongly quenched by oxygen whereas fluorescence remains unaffected, allows these compounds to be used as ratiometric oxygen sensors in chemical and biological media. Both steady-state (fluorescence vs phosphorescence intensities) oxygen concentration) luminescence approaches can be used. Photocytotoxicity studies against human melanocytic melanoma cells (A375) indicate that these compounds display potential as and dynamic (dependence of phosphorescence lifetimes upon hotocytotoxicity studies against human melanocytic melanoma photosensitizers in photodynamic therapy.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6