The diagnostic and prognostic role of liquid-based cytology: are we ready to monitor therapy and resistance?

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2015

Autores

Rossi, ED (Autor) Outra; Bizzarro, T (Autor) Outra; Longatto, A (Autor) Outra; Gerhard, R (Autor) Outra; Fernando Schmitt (Autor) FMUP

Revista

Título: Expert Review of Anticancer Therapy

Vol. 15

Páginas: 911-921

ISSN: 1473-7140

Editora: Taylor & Francis

Indexação

ISI Web of Knowledge - 17 Citações

Scopus - 20 Citações

Outras Informações

ID Authenticus: P-00G-EKZ

DOI: 10.1586/14737140.2015.1053874

Abstract (EN): Here, we evaluate the diagnostic and prognostic role of liquid-based cytology (LBC) in different body lesions, including thyroid, lung, effusions and malignant breast lesions. LBC has gained consensus after being applied to both non-gynecologic and fine-needle aspiration cytology. Although some remain sceptical regarding the diagnostic efficacy of LBC, mainly when used alone, in recent years, good results have been obtained as long as it showed a high diagnostic accuracy. Here, we discuss the additional possibility of storing material for the application of ancillary techniques (immunocytochemistry-molecular analysis) with several diagnostic and prognostic advantages, which may pave the way for the challenging evaluation of both monitoring responses to treatment and resistance to targeted therapies in thyroid, lung, breast carcinoma or malignant effusions. Furthermore, it provides the use of several molecular spots as specific targets for personalized therapy.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 11