Profiling Persistent Asthma Phenotypes in Adolescents: A Longitudinal Diagnostic Evaluation from the INSPIRERS Studies

• Tipo: Artigo em Revista Científica Internacional
• Data: 2021

Autores

Amaral, R (Autor) FMUP; Jacome, C (Autor) FMUP; Almeida, R (Autor) FMUP; Pereira, AM (Autor) FMUP; Alves Correia, M (Autor) Outra; Mendes, S (Autor) Outra; Rodrigues, JCC (Autor) Outra; Carvalho, J (Autor) Outra; Araujo, L (Autor) FMUP; Costa, A (Autor) Outra; Silva, A (Autor) Outra; Teixeira, MF (Autor) Outra; Ferreira Magalhaes, M (Autor) Outra; Alves, RR (Autor) Outra; Moreira, AS (Autor) Outra; Fernandes, RM (Autor) Outra; Ferreira, R (Autor) Outra; Pinto, PL (Autor) Outra; Neuparth, N (Autor) Outra; Bordalo, D (Autor) FMUP; Bom, AT (Autor) Outra; Calix, MJ (Autor) Outra; Ferreira, T (Autor) Outra; Gomes, J (Autor) Outra; Vidal, C (Autor) Outra; Mendes, A (Autor) Outra; Vasconcelos, MJ (Autor) Outra; Silva, PM (Autor) Outra; Ferraz, J (Autor) Outra; Morete, A (Autor) Outra; Pinto, CS (Autor) Outra; Santos, N (Autor) Outra; Loureiro, CC (Autor) Outra; Arrobas, A (Autor) Outra; Marques, ML (Autor) Outra; Lozoya, C (Autor) Outra; Lopes, C (Autor) FMUP; Cardia, F (Autor) Outra; Loureiro, CC (Autor) Outra; Camara, R (Autor) Outra; Vieira, I (Autor) Outra; da Silva, S (Autor) Outra; Silva, E (Autor) Outra; Rodrigues, N (Autor) Outra; Fonseca, J (Autor) FMUP

Revista

Título: International Journal of Environmental Research and Public Health

Vol. 18 Nº 5

Páginas: 1-11

ISSN: 1661-7827

Editora: MDPI

Indexação

ISI Web of Knowledge - 5 Citações

Scopus - 6 Citações

Outras Informações

ID Authenticus: P-00T-BS6

DOI: 10.3390/ijerph18031015

Abstract (EN): We aimed to identify persistent asthma phenotypes among adolescents and to evaluate longitudinally asthma-related outcomes across phenotypes. Adolescents (13-17 years) from the prospective, observational, and multicenter INSPIRERS studies, conducted in Portugal and Spain, were included (n = 162). Latent class analysis was applied to demographic, environmental, and clinical variables, collected at a baseline medical visit. Longitudinal differences in clinical variables were assessed at a 4-month follow-up telephone contact (n = 128). Three classes/phenotypes of persistent asthma were identified. Adolescents in class 1 (n = 87) were highly symptomatic at baseline and presented the highest number of unscheduled healthcare visits per month and exacerbations per month, both at baseline and follow-up. Class 2 (n = 32) was characterized by female predominance, more frequent obesity, and uncontrolled upper/lower airways symptoms at baseline. At follow-up, there was a significant increase in the proportion of controlled lower airway symptoms (p < 0.001). Class 3 (n = 43) included mostly males with controlled lower airways symptoms; at follow-up, while keeping symptom control, there was a significant increase in exacerbations/month (p = 0.015). We have identified distinct phenotypes of persistent asthma in adolescents with different patterns in longitudinal asthma-related outcomes, supporting the importance of profiling asthma phenotypes in predicting disease outcomes that might inform targeted interventions and reduce future risk.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 11