Chlorinated Flavonoids Modulate the Inflammatory Process in Human Blood

• Tipo: Artigo em Revista Científica Internacional
• Data: 2017

Autores

Proenca, C (Autor) Outra; Ribeiro, D (Autor) Outra; Soares, T (Autor) Outra; Tome, SM (Autor) Outra; Silva, AMS (Autor) Outra; Lima, JLFC (Autor) FMUP; Eduarda Fernandes (Autor) FFUP; Freitas, M (Autor) Outra

Revista

Título: Inflammation

Vol. 40

Páginas: 1155-1165

ISSN: 0360-3997

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 5 Citações

Scopus - 8 Citações

Outras Informações

ID Authenticus: P-00M-PKH

DOI: 10.1007/s10753-017-0559-8

Abstract (EN): Flavonoids are known to react with neutrophil-generated hypochlorous acid (HOCl) at inflammation loci to form stable mono- and dichlorinated products. Some of these products have been shown to retain or even enhance their inflammatory potential, but further information is required in a broader approach to inflammatory mechanisms. In that sense, we performed an integrated evaluation on the anti-inflammatory potential of a panel of novel chlorinated flavonoids and their parent compounds, in several steps of the complex inflammatory cascade, namely, in the activity of cyclooxygenase (COX)-1 and COX-2, and in the production of cytokines [interleukin (IL)-6, IL-1 beta, tumor necrosis factor (TNF)], and the chemokine, IL-8, as well as in the production of reactive species, using human whole blood as a representative in vitro model, establishing, whenever possible, a structure-activity relationship. Although luteolin was the most active compound, chlorinated flavonoids demonstrated a remarkable pattern of activity for the resolution of the inflammatory processes. Our results demonstrated that 6-chloro-3',4',5,7-tetrahydroxyflavone deserves scientific attention due to its ability to modulate the reactive species and cytokines/chemokine production. In this regard, the therapeutic potential of flavonoids' metabolites, and in this particular case the chlorinated flavonoids, should not be neglected.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 11