Erythropoietin Reduces Acute Lung Injury and Multiple Organ Failure/Dysfunction Associated to a Scald-Burn Inflammatory Injury in the Rat

• Tipo: Artigo em Revista Científica Internacional
• Data: 2015

Autores

Rocha, J (Autor) Outra; Eduardo Figueira, M (Autor) Outra; Barateiro, A (Autor) Outra; Fernandes, A (Autor) Outra; Brites, D (Autor) Outra; Pinto, R (Autor) Outra; Freitas, M (Autor) Outra; Eduarda Fernandes (Autor) FFUP; Mota Filipe, H (Autor) Outra; Sepodes, B (Autor) Outra

Revista

Título: Inflammation

Vol. 38

Páginas: 312-326

ISSN: 0360-3997

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 18 Citações

Scopus - 20 Citações

Outras Informações

ID Authenticus: P-00G-16W

DOI: 10.1007/s10753-014-0035-7

Abstract (EN): Erythropoietin (EPO) is an endogenous regulator of erythropoiesis and is given exogenously as a replacement therapy for selected red blood cell disorders. In the past years, EPO has been emerging as a multifunctional, cytoprotective cytokine with anti-apoptotic, anti-inflammatory, and immunomodulatory properties. We aimed to evaluate the cytoprotective effect of rhEPO (recombinant human EPO) treatment on a rat model of multiorgan dysfunction induced by thermal injury. rhEPO was administered at 1000 U/kg (i.v.) 5 min prior to induction of injury and significantly reduced multiorgan dysfunction markers (liver, kidney, lung, serum cytokine levels). In the lung, rhEPO reduced: histological signs of tissue injury, inflammatory/injury markers on the bronchoalveolar fluid, neutrophil chemotaxis/infiltration, GSK-3 beta activation, and apoptosis. Our study showed that erythropoietin has the potential to exhibit pleiotropic cytoprotective effects and that it might be an interesting pharmacological strategy in the modulation of acute lung injury, such as the one associated to severe burn.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 15