The role of estrogens and estrogen receptor signaling pathways in cancer and infertility: the case of schistosomes

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2015

Autores

Botelho, MC (Autor) Outra; Alves, H (Autor) Outra; barros, a (Autor) FMUP; Rinaldi, G (Autor) Outra; Brindley, PJ (Autor) Outra; sousa, m (Autor) ICBAS

Revista

Título: Trends in Parasitology

Vol. 31

Páginas: 246-250

ISSN: 1471-4922

Editora: Elsevier

Indexação

ISI Web of Knowledge - 22 Citações

Scopus - 24 Citações

Outras Informações

ID Authenticus: P-00G-621

DOI: 10.1016/j.pt.2015.03.005

Abstract (EN): Schistosoma haematobium, a parasitic flatworm that infects more than 100 million people, mostly in the developing world, is the causative agent of urogenital schistosomiasis, and is associated with a high incidence of squamous cell carcinoma (SCC) of the bladder. Schistosomiasis haematobia also appears to negatively influence fertility, and is particularly associated with female infertility. Given that estrogens and estrogen receptors are key players in human reproduction, we speculate that schistosome estrogen-like molecules may contribute to infertility through hormonal imbalances. Here, we review recent findings on the role of estrogens and estrogen receptors on both carcinogenesis and infertility associated with urogenital schistosomiasis and discuss the basic hormonal mechanisms that might be common in cancer and infertility.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5