Gold nanoparticles for the development of clinical diagnosis methods

• Type: Another Publication in an International Scientific Journal
• Date: 2008

Authors

Pedro Baptista (Author) Other; Eulalia Pereira (Author) FCUP; Peter Eaton (Author) Other; Goncalo Doria (Author) Other; Adelaide Miranda (Author) Other; Ines Gomes (Author) Other; Pedro Quaresma (Author) Other; Ricardo Franco (Author) Other

Journal

Title: Analytical and Bioanalytical Chemistry

Vol. 391

Pages: 943-950

ISSN: 1618-2642

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 294 Citations

Scopus - 211 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-003-YMF

DOI: 10.1007/s00216-007-1768-z

Abstract (EN): The impact of advances in nanotechnology is particularly relevant in biodiagnostics, where nanoparticle-based assays have been developed for specific detection of bioanalytes of clinical interest. Gold nanoparticles show easily tuned physical properties, including unique optical properties, robustness, and high surface areas, making them ideal candidates for developing biomarker platforms. Modulation of these physicochemical properties can be easily achieved by adequate synthetic strategies and give gold nanoparticles advantages over conventional detection methods currently used in clinical diagnostics. The surface of gold nanoparticles can be tailored by ligand functionalization to selectively bind biomarkers. Thiol-linking of DNA and chemical functionalization of gold nanoparticles for specific protein/antibody binding are the most common approaches. Simple and inexpensive methods based on these bio-nanoprobes were initially applied for detection of specific DNA sequences and are presently being expanded to clinical diagnosis.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8