In vitro degradation behavior of a novel bioresorbable composite material based on PLA and a soluble CaP glass

• Type: Article in International Scientific Journal
• Date: 2005

Authors

Navarro, M (Author) Other; Ginebra, MP (Author) Other; Planell, JA (Author) Other; Barrias, CC (Author) Other; Mário Adolfo Barbosa (Author) FEUP

Journal

Title: Acta Biomaterialia

Vol. 1

Pages: 411-419

ISSN: 1742-7061

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 46 Citations

Scopus - 47 Citations

Other information

Authenticus ID: P-000-2DC

DOI: 10.1016/j.actbio.2005.03.004

Abstract (EN): Poly(α-hydroxy acids), and in particular polylactic acid (PLA), are nowadays amongst the most used bioabsorbable materials. However, this polymer may not meet some application requirements due to inadequate mechanical properties and or its degradation characteristics. A possible strategy to tackle this problem is the incorporation of an inorganic phase into the polymeric matrix. In this work a new fully biodegradable composite material made with PLA and calcium phosphate soluble glass particles has been developed. The behaviour of the PLA/ glass composite has been analysed during its degradation in simulated physiological conditions by means of weight loss, molecular weight and thermal properties analysis and electron microscopy observation. The results showed that the incorporation of phosphate glass particles into the polymer significantly accelerated the degradation of the PLA and induced the formation of calcium phosphate precipitates at the composite surface.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9