PLGA nanoparticles as a platform for vitamin D-based cancer therapy

• Type: Article in International Scientific Journal
• Date: 2015

Authors

M. Carmo Pereira (Author) FEUP; Maria J. Ramalho (Author) FEUP; Joana A. Loureiro (Author) FEUP; Manuela F. Frasco (Author) FEUP; Manuel A. N. Coelho (Author) FEUP

Journal

Title: Beilstein Journal of Nanotechnology

Vol. 6

Pages: 1306-1318

ISSN: 2190-4286

Publisher: Beilstein-Institut Zur Forderung der Chemischen Wissenschaften

Indexing

ISI Web of Knowledge - 20 Citations

Scopus - 26 Citations

Scientific classification

CORDIS: Health sciences ; Technological sciences

FOS: Engineering and technology ; Medical and Health sciences

Associated Projects

BIONANO - Distibuição de biomoleculas através de nanopartículas inorganica/organicas

PTDC/QUI-BIQ/118076/2010 - Liposomas funcionalizados com anticorpos para a doença de Alzheimer

LEPABE - Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia

Other information

Authenticus ID: P-00G-BQN

DOI: 10.3762/bjnano.6.135

Abstract (EN): Poly(lactic-co-glycolic acid) (PLGA) nanoparticles were studied as drug delivery vehicles for calcitriol, the active form of vitamin D-3. In vitro effects of calcitriol encapsulated in PLGA nanoparticles were evaluated with respect to free calcitriol on human pancreatic cell lines, S2-013 and hTERT-HPNE, and the lung cancer cell line A549. Encapsulated calcitriol retained its biological activity, reducing the cell growth. Cytotoxicity assays demonstrated that encapsulation of calcitriol enhanced its inhibitory effect on cell growth at a concentration of 2.4 mu M for the S2-013 cells (91%) and for A549 cells (70%) comparared to the free calcitriol results. At this concentration the inhibitory effect on nontumor cells (hTERT-HPNE) decreased to 65%. This study highlights the ability of PLGA nanoparticles to deliver vitamin D-3 into cancer cells, with major effects regarding cancer cell cycle arrest and major changes in the cell morphological features.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 13